In the late 2000s, Brooke Shields guest-starred on shows like FX's Nip/Tuck and CBS' Two and a Half Men. In 2005, Shields appeared in a season-two episode of HBO's Entourage, entitled "Blue Balls Lagoon."

Brooke Shields recorded the narration for the Sony/BMG recording of The Runaway Bunny, a concerto for violin, orchestra, and reader, by Glen Roven. It was performed by the Royal Philharmonic and Ittai Shapira.

Brooke Shields made a couple of guest appearances on That '70s Show. She played Pam Burkhart, Jackie's (Mila Kunis) mother, who later was briefly involved with Donna's (Laura Prepon) father (played by Don Stark). Shields left That '70s Show when her character was written out.

In the early 1980s, Brooke Shields starred in the USPHS PSA sponsored by the American Lung Association as an initiative that VIPs should become examples and advocates of non-smoking. In the mid-1980s, Brooke began her support of the USO by touring with Bob Hope.

Brooke Shields was also the youngest person to host ABC's Fridays, a Saturday Night Live-like sketch comedy show, in 1981. In one episode of the popular comedy sitcom Friends, Shields played Joey's stalker. This role led directly to her being cast in the NBC sitcom Suddenly Susan, in which she starred from 1996 until 2000, and which earned a People's Choice Award.

Brooke Shields began her television career at an early age. In 1980, she was the youngest guest star to ever appear on The Muppet Show, in which she and the Muppets put on their own version of Alice's Adventures in Wonderland.

In 2001, Lifetime aired the film What Makes a Family, starring Brooke Shields and Cherry Jones in a true story of a lesbian couple who fought the adoption laws of Florida.

Brooke Shields won the People's Choice Award in the category of Favorite Young Performer in four consecutive years from 1981 to 1984. In 1998, she played a lesbian, Lily, in The Misadventures of Margaret.