Brooke Shields has been married twice. From 1997 to 1999, she was married to tennis player Andre Agassi; the couple had been together since 1993. Following her divorce from Agassi, she married television writer Chris Henchy in 2001, after they had met through mutual friends in 1999. They have two daughters and live in Greenwich Village, Manhattan, New York City.

Brooke Shields is a well-known vegan and an animal rights activist. However, despite coming out against the fur industry in 1989, Shields later went on to create her own mink fur coat at Kopenhagen Fur. She came under the scrutiny of animal rights organizations such as PETA for this visit, which prompted media attention.

In the 1990s, Brooke Shields promoted physical fitness as an extension of femininity, maintaining that femininity and athletics are compatible. Although she was not the only woman doing so, Shields had what was required to promote women's athletics.

In September 2004, Shields replaced Donna Murphy in the role of Ruth Sherwood in the 2003 revival of Wonderful Town until the show closed four months later. Her performance was widely praised.

Shields has appeared in several Broadway musical theater productions. She played Rizzo in the 1994 revival of Grease. For four months, beginning July 2001, she played Sally Bowles in the long-running 1998 revival of Cabaret.

Brooke Shields also appeared as a featured celebrity in NBC's genealogy documentary reality series, Who Do You Think You Are?, where it was revealed that, through her father's ancestry, she is the distant cousin (many generations removed) of King Louis XIV of France, and thus a descendant of both Saint Louis and Henry IV of France.

Starting in 2010, Brooke Shields made guest appearances on The Middle as the mother of a brood of terror-inducing children and the nemesis of Frankie Heck (played by Patricia Heaton).

In 2007, Brooke Shields made a guest appearance on Disney's Hannah Montana, playing Susan Stewart, Miley and Jackson's mother, who died in 2004. In 2008, she returned in the primetime drama Lipstick Jungle.